Experimental models for evaluation of anti hyperlipidemic activity the antihyperlipidemic activity was performed by two experimental models,triton x 100 induced hyperlipidemiaand high fat diet induced hyperlipidemia. Compound 3 was one of the most active agents elevating the hdl cholesterol level by 56% and lowering the ldl cholesterol level by 46. Hypolipidemic activity of chloroform extract of mimosa pudica leaves 218 avicenna journal of medical biotechnology, vol. Hypolipidemic effect of extracts from abelmoschus esculentus. They are however soluble in other organic solvents such as ether, acetone and other.
New chemical structures of hypolipidemic and antiplatelet. Lipidlowering activity of medicinal plant for phytomedicine research and drug development for such a disease are now focused all over the world. Hypolipidemic activity of rifamycin derivatives journal of. Histopathological findings also supported the protective role of mimosa pudica chloroform extract in preventing atherogenic diet induced hepatic, liver and kidney steatosis. Files available from the acs website may be downloaded for personal use only. Hypolipidemic and antioxidant activity of enoki mushrooms. The present study investigated the antioxidant and hypolipidemic activity of hydroethanolic extract of curatella americana l. Researcharticle deciphering molecular mechanism underlying hypolipidemic activity of echinocystic acid lihan,penglai,andjunrongdu departmentofpharmacology. Triton x 100 induced hyperlipidemia model10 thirty wistar rats were randomly divided into 5 groups of 6 each. From the data shown in table 4, fve has a strong antioxidative effect 99. The present study was, therefore, undertaken to study the m. Akpan1 1department of biochemistry, university of uyo, uyo, nigeria.
Pdf hypolipidemic activity of gum ghatti of anogeissus. Hypolipidemic activity of rifamycin derivatives journal. Antidiabetic and hypolipidemic activities of ethanolic leaf. Hypolipidemic activity of methanolic extract of terminalia. May become of importance for human clinical treatment.
Or these are drugs which lowers the level of lipids and lipoproteins in blood. Haritaki consists of dried pericarp of mature fruits of terminalia chebula belonging to family combretaceae. It is traditionally used for its various properties and hence in the present study, chloroform extract of mimosa pudica leaves has been screened for its hypolipidemic activity. The activity was observed in a dose dependent manner for all. However bark extract exhibited the hypolipidemic effect on day 15 and day 30 at the tested dose of 125 mgkg b. Several antihyperlipidemic agents are currently available. Considering the hypolipidemic activity in rats at a dose of 80 mgkgday, some isomers were more potent than clofibrate at 150 mgkg. Evaluation of antidiabetic and hypolipidemic activities of the extract and fractions induction of diabetes and animal treatment the animals male rats were fasted for 24hours and diabetes was induced by a single intraperitoneal injection of a freshly prepared solution of alloxan monohydrate 150mgkg in ice cold 0. Hypoglycemic and hypolipidemic effects of seed extract. Histopathological findings in rat liver supported the protective role of h. Previously, we have reported that cs produced a potent antihyperglycaemic activity in stz diabetic rats eddouks et al. In vivo and in vitro antioxidant and hypolipidemic activity.
The antioxidant activity and hypolipidemic activity of the. Comparison of hypolipidemic effect of extracts from total plant and fruit a notable reduction in cholesterol levels of mice treated with the extracts was observed 24 hours after tyloxapol injection. Veeramani department of pharmacy, annamalai university, annamalai nagar, tamilnadu, india 608002. There is, however, quite a numerous group of structures that are claimed as hypoglycemic andor hypolipidemic and antiplatelet, etc. Hypolipidemic activity of ginkgo biloba extract in hypercholesterolemic rats ijpt. Triton model rats received a single dose of methanolic extract of terminalia arjuna leaves metal orally at 500 mg kg 1 b. Based on the above evaluation of hypolipidemic activity of leaf juice of catharanthus roseuslinn. High levels of specific lipoproteins, namely, lowdensity lipoprotein ldl and very lowdensity lipoprotein. Anti hyperlipidemic, black catechu, fenugreek, cholesterol, triglyc. Hypolipidemic effect of extracts from abelmoschus esculentus l. Synthesis and hypolipidemic and antiplatelet activities of.
Further experiments will possibly define this pharmacological effect and active constituents. In vivo and in vitro antioxidant and hypolipidemic. Hypolipidemic agents, cholesterollowering drugs or antihyperlipidemic agents, are a diverse group of pharmaceuticals that are used in the treatment of high levels of fats lipids, such as cholesterol, in the blood hyperlipidemia. In the present study, the whole methanolic extract of garcinia indica exhibited a significant antihyperlipidemic activity in cholesterol induced hyperlipidemic model in albino wistar rats which was better than that observed with standard drug lovastatin. Antidiabetic and hypolipidemic activities of ethanolic leaf extract and fractions of carpolobia lutea maurice m.
Cholic acid and desoxycholic acid in feces were estimated at the end of the study on day 30. Hypolipidemic activity of ginkgo biloba extract, egb 761 in. Antioxidant and hypolipidemic activity of the hydroethanolic. Results indicated that leaf extract exhibited hypolipidemic activity on day 30 at dose levels 250 and 500 mgkg b. Hypolipidemic activity of aqueous extract of capparis. Hyperlipidemia is a very important major cause of cardiovascular disorder. The antioxidant activity of exc was assessed by 2,2diphenyl1picrylhydrazyl free radical. Hypolipidemic activity of symplocos cochinchinensis s. Original article effects of total flavonoids extracted from. The observed hypolipidemic activity may be further confirmed by the previous studies of the different types of plant extracts 19, 20. Lipoproteins bind cholesterol and can accumulate in blood vessels. Hypolipidemic activity of methanolic extract of terminalia arjuna leaves was evaluated in two hyperlipidemic rat models viz.
Albahrawy2, shaik rahiman3 1department of pathology, college of medicine, aljouf university, aljouf, saudi arabia 2. Veeramani department of pharmacy, annamalai university, annamalai nagar, tamilnadu, india 608002 corresponding author. Lipoproteins are classified into sixclasses based on their particle size anddensity 2. Deciphering molecular mechanism underlying hypolipidemic. Hypolipidemic activities of a series of pyrazoles of curcumin. Drugs which lower the level of lipidsand lipoproteins in blood. Recently use of herbal therapies and diet rich in flavonoids and vitamins has augmented significantly to manage minor to modest illnesses. Malvaceae on tyloxapolinduced hyperlipidemia in mice t. The activity of the glucose 6 phosphate dehydrogenase enzyme in the compound 3b treated tubes was found to be 28. The purpose of this study was to examine the effect of single and repeated oral administrations of the aqueous extract of capparis spinosa l.
Thats why more people are switching towards safer alternatives, specially derived from plants with fewer side effects. Caesalpiniaceae seeds extract have been studied in two models of hyperlipidemia in rats. This research aimed to evaluate the bioactive composition and antioxidant and hypolipidemic effects of total flavonoids extracted from polygonum perfoliatum l. Vo phung1 1department of pharmacology, 2department of pharmacognosy, school of pharmacy at ho chi minh city, vietnam. Moore leaves was studied in triton wr39 and high fat dietinduced hyperlipidemic rats. In guinea pigs yogesh patel1, vishalkumar vadgama1, seema baxi2 and chandrabhanu. Cs at a dose of 20 mgkg on lipid metabolism in normal and streptozotocininduced diabetic rats. High levels of reactive oxygen species in the body and hyperlipidemia are key factors for the development of cardiovascular diseases such as atherosclerosis. Lipids are very diverse in both their respective structures and functions. Hplc analysis results showed the main flavonoids composition of tfp were quercetin and rutin. Major lipid groups include fats, phospholipids, steroids and waxes. Hypolipidemic activity of pithecellobium dulce in triton. The hypolipidemic activity of hibiscus rosa sinensis root was compared with a standard drug guggulipid 200 mgkg body wtday p.
Hypolipidemic activity of ce may be attributed due to presence of carbohydrates, tannins, flavonoids and fixed oils. Hypolipidemic activity of hibiscus rosa sinensis root in rats. Hypolipidemic activity of aqueous extract of capparis spinosa. Jul 20, 2015 in addition, these compounds demonstrate hypocholesterolemic and hypolipidemic action. The values measured on day 30 showed that there was a significant fall in serum cholesterol in both lovastatin and ginkgo biloba treated groups. Antihyperlipidemic activity of the medicinal plants among. A significant hypocholesterolaemic effect of trigonella foenumgraecum has been well documented by several authors from animal and clinical study. In an acute model, hyperlipidemia was induced by injecting a single dose of triton wr39 400 mgkg, b. The antihyperlipidaemic activity of herbs plays an important role in the reduction of cardiovascular diseases, which is the top disease that causes mortality all over the world. Hypolipidemic activity of chloroform extract of mimosa. Hypolipidemic drug, any agent the reduces the level of lipids and lipoproteins lipidprotein complexes in the blood.
Hypolipidemic activity of pithecellobium dulce in triton wr. In vivo and in vitro antioxidant and hypolipidemic activity of methanol extract of pineapple peels in wistar rats ejiofor u. Jun 18, 2011 the hypolipidemic activity of symplocos cochinchinensis s. Hypolipidemic definition of hypolipidemic by medical dictionary. Triton wr39 induced hyperlipidemia acute model this model is widely used in order to screen natural or synthetic drugs.
It is well known that the level of glycemic control is the major determinant of plasma vldl and triglycerides levels. Antidiabetic and hypolipidemic activities of ethanolic. In normal rats, the aqueous extract of cs induced a significant decrease on plasma triglycerides concentrations 1 week p hypoli pidemic activity of fe may be attributed due to presence of steroi dal saponins, alkaloids and free amino acids. Triton wr39, a nonionic detergent oxy ethylated tertiary octyl phenol formaldehyde polymer can causes acute hyperlipidemia. The hypolipidemic activity of cassia tora chakvat, chakunda family. High levels of specific lipoproteins, namely, lowdensity lipoprotein ldl and very lowdensity lipoprotein vldl, have been associated with an elevated risk of. Hypoli pidemic activity of fe may be attributed due to presence of steroi dal saponins, alkaloids and free amino acids. Evaluation of the antihyperlipidemic activity of nelumbo. Screening for hypolipidemic activity screening for hypolipidemic activity was carried out in albino rats wistar strain weighing 100200 g of either sex maintained in standard conditions for temperature, relative humidity, and lightday cycles and. Glucoselowering, hepatoprotective and hypolipidemic. The most active compound 5 decreases the triglyceride, total cholesterol, and low. Hypolipidemic activity of pithecellobium dulce bench. In triton wr39induced hyperlipidemic rats, the hexane extract 250 and 500 mgkg exerted a significant p hypolipidemic. Hypolipidemic activity of chloroform extract of mimosa pudica.
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